Simplify mesh

I had some artifacts on a model printed in Vase-mode.  I couldn't understand it because a simple cylinder printed perfectly in vase mode.  I figured I would connect with Prusa Chat to,see what I could learn. After they looked at the model & photos, they attributed it to the head hitting the model.  Prusa Chat is excellent and they have been very helpful in the past, but once in a while, they don't think "model."  They tend to jump to hardware.  
So, I decided to figure this out with the help of the Internet, which just sent me to some crazy solutions that just made no sense.  I did remember that the model came in with errors, which I fixed with Slicer, and it was a huge file.  It came from Pritables.com and was likely from a 3D scan.  Plus, I reduced its original size by 50%.  What was happening is the model had these super-tiny tool paths that the printer just couldn't handle, leaving a small glob of filement at these points...likely worsened by the reduced scale, making those paths extremely tiny.So, I decided to use Simply Model command as I watched the traiangles greatly reduce with some setting changes, and the file reduced in size too.  I printed it and the issue was 100% corrected, and the print head moved super smooth, as opposed to jerking all over the place, unnecessarily.
Lessone Learned: If you load a model into slicer and you get a File Size Warning, condsider Simplify Model.  Otherwise your printer just works too hard and there is more chance for artifacts as it navigates those tiny tool paths.
 

It would be helpful to know what if any downsides exist to simplifying a mesh, when to do it, when not, what to look for and think about when using it. The article mentions a Low-Poly effect but doesn't say what that is or provide a link so people can learn about it. The article is simple, but perhaps too simple.
So this page is useful but I could not give it a thumbs up or thumbs down because there are reasons to give it both. The Tumbs-Up / Thumbs Down, Like or Dislike systems of rating don't leave room for any other evaluative responses because they are binary. Maybe there are things to like and dislike about a page and other response options need to be available.

I had a particularly enormous and troublesome STL file I needed to work with (25 Mb and some ungodly number of meshes). I tried 3 different CAD programs in an effort to just open the damn thing up and simplify it to be able to even work with it, and every single one of them would just crash on it.
I thought I remebered a simplfy file feature in my slcier....well, Prusaslicer to the rescue! I kept the highest level of detail, lost absolutely nothing in the process and the slicer had the file down to a workable size in about 5 seconds!