PrusaSlicer separates the printer connection settings from the Printer profile into a Physical printer profile.
For the best experience and full feature set, we recommend configuring PrusaConnect directly through the PrusaConnect tab rather than through the Physical printer dialog.

You can create a new Physical profile by clicking Add printer in the printer profile select box or by clicking the cog icon and picking Add physical printer.

In the Physical printer dialog, you can name the printer and assign it one or more printer profiles. If you're using, for example, the MMU2S upgrade, you only have to set one physical printer, but you can have both Single mode and MMU profiles linked to it.

If you have a Physical printer with network info filled out selected as your current printer, you can send generated G-codes directly to your device.
PrusaConnect
If you'd like to send files to your printer via PrusaConnect, add a Physical printer or Edit an existing one.
Select PrusaConnect from the select box as the Host type. The hostname/IP will be automatically filled, you don't have to change it.

To find your API key, go to PrusaConnect, select the printer you want to send the files to, go to the Settings tab and scroll down to he API keys section. Copy PrusaConnect API key to the Physical printer window and confirm with OK.

15 comments
I looked at I have a physical printer profile, but I can't edit it and I'm using a different nozzle now. I went to set up a new physical printer, but it forces me to select a host profile, and exactly zero of them are "Prusa" anything, so I can't set up my printer as a physical one.
One, why break what was working? Two, why can't I tell it to make my printer a physical one directly and then input my IP and API? Three, Prusa connect can see my printer in the built in prusa slicer interface, but I can't send it from my slicer to connect directly, and I have to export the gcode file to my computer and then drag and drop it to the upload slot on prusa slicer in the connect page to get it to upload and print.
WTF?
However, the article only seems to cover prusaconnect and doesn't have any information about sending Gcode over the network